Total Parenteral Nutrition (TPN) is pharmacological therapies where nutrients, vitamins, electrolytes and medications are delivered via the venous route to those patients whose gastrointestinal tract is not functioning and are unable to tolerate enteral nutrition. TPN is an effective means of sustaining life and promoting recovery in critically ill patients incapable of ingesting, absorbing or assimilating nutrients. Infants in the Neonatal Intensive Care Unit (NICU) often require nutrition support. Infants who are critically ill and cannot be breastfed are started on TPN that is planned meticulously from Day one of life itself.